|Baltic Dental and Maxillofacial Journal|
March, 2010, Vol. 12, No. 1
© 2010 Stomatologija
Stomatologija 2010; 12 (1): 28-32 639 KB
Functional activity of rabbit salivary glands in reduced and restored regional arterial blood supply conditions
Kaspars Stamers, Andrejs Skagers, Kalvis Pastars, Nonna Tomisheva, Maija Ratniece
Background. Although the vascular pathology of carotid arteries is widespread, the function of salivary glands in reduced arterial flow conditions is not much investigated clinically and in experiments. At the same time blood supply is a keystone to normal functioning of every organ and especially of salivary secretion. The aim of this study was to estimate functional activity of salivary glands in reduced and restored blood supply conditions in experiment by sialoscintigraphy which is an approved method for functional assessment of salivary glands.
Methods. The ligature of a. carotis communis dextra was performed on 20 Californian rabbits. After 28 days sialoscintigraphy with Tc99 pertechnetate and revascularization through resection of the occluded part of a. carotis communis and reconstruction with venous autograft was performed. One month later sialoscintigraphy was done.
Results. The functional activity of rabbit salivary glands after the ligature of a. carotis communis is strongly depressed. The revascularized glands accumulated isotope slowly, but the level of accumulation was higher than on the control side.
Conclusion. The ligature and reconstruction of a common carotid artery on rabbits confirm the important role of the arterial blood supply in functional activity of salivary glands and may be an appropriate experimental model for investigation of ischemic disease of salivary glands.
Key words: sialoscintigraphy, carotid artery ligature.
Received: 13 10 2009
Accepted for publishing: 26 03 2010
1Department of Oral and Maxillofacial Surgery, Riga Stradins University, Riga, Latvia
2Department of Reconstructive Microsurgery, University Hospital "Gailezers", Riga, Latvia
3Department of Radionuclide Diagnostics, Stradins University Hospital, Riga, Latvia
Kaspars Stamers1 MD, D.D.S.
Andrejs Skagers1 MD, Dr. hab. med, professor, Head of Department of Oral and Maxillofacial Surgery
Kalvis Pastars2 MD
Nonna Tomisheva2 MD
Maija Ratniece3 MD
Address correspondence to Kaspars Stamers, Department of Oral and Maxillofacial Surgery, Dzirciema str. 20, Riga LV 1007, Latvia.
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